Hypersensitivity to antiretroviral drugs a case report

Methods We report a case of a 47-year-old woman, with diagnosis of HIV infection since 2009 (HLA B5701 negative) that started ARVT in 2011. On the 2nd day of treatment with Tenofovir, Emtricitabine and Nevirapine she developed pruritic exanthema and palpebral edema. Two weeks later the Infecciologist discontinued ARVT and prescribed AH (antihistamines) and CS (oral corticosteroids) with symptoms resolution. One month later treatment with Tenofovir and Emtricitabine was restarted in association with Darunavir and Ritonavir. There was a reproducible reaction on the 2nd day of treatment. After the reaction subsided, the patient restarted Darunavir and Ritonavir in association with Abacavir and Lamivudine. On the 2nd day she developed palpebral edema and discontinued ARVT once again. She was then referred to our Drug Allergy Clinic for suspected hypersensitivity to ARVT.